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In general, evidence from RCTs does not show that vitamin B12 supplementation alone or with folic acid, vitamin B6, or both for 1 to 2 years improves cognitive function in older adults with or without dementia, mild cognitive impairment, or Alzheimers disease, even though supplementation lowers homocysteine levels [93-96]

Those most at risk of a Vitamin B12 deficiency include elderly people, those who follow a vegetarian or vegan diet, people who have had intestinal surgery and people with diseases of the gut, such as Crohn's Disease or Celiac Disease

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Adults over the age of 65 Due to a number of common issues associated with ageing, including the reduced production of stomach acid, men and women over the age of 65 may be more prone to a B12 deficiency

Moreover, increased homocysteine levels due to vitamin B12 deficiency could induce neurotoxicity caused by oxidative stress