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Miller RA: The aging immune system: primer and prospectus

C9orf72 was also shown to be a Rab guanine exchange factor (GEF) involved in the modulation of Rab activity (Iyer et al., 2018), which regulates NOX2 recruitment to phagosomes in dendritic cells (Jancic et al., 2007)

394,395 Other signalings can interact with Hippo pathway to promote HCC, such as Notch pathway, EGFR signals, AKT pathway and DDR1 signaling 396,397,398,399 Considering the oncogenic roles of YAP in liver cancer and other disease, it is attractive to develop inhibitors targeting YAP

Helper or cytotoxic T cells secrete factors such as interferon- (IFN-) and IL-17 that compromise cartilage integrity ( Although dendritic cells (DCs) and natural killer (NK) cells are less abundant in OA synovium compared with macrophages and T cells, they can still influence synovitis severity and iron homeostasis by secreting inflammatory mediators or cooperating with T cells