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The rationale for combining them is mechanistic complementarity (different signaling pathways, all three implicated in tissue repair and dermal remodeling) and clinical anecdote in the peptide-therapy community not formal head-to-head, combination-vs-monotherapy, or concentration-response data on the blend itself

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Amino acid mutations in the H-site can significantly alter the catalytical activity of GST enzymes towards their substrates [88, 89]

In the subsections that follow, we discuss extract-based CFE systems, extract preparation methods, CFE reaction components and energy systems, purified CFE systems, CFE reaction formats and scale, monitoring CFE reactions, high-throughput experimentation for CFE, and modeling CFE systems