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Doxorubicin analogues Doxorubicin (DOX) is a common topoisomerase II inhibitor widely used in the treatment of solid tumors and malignant hematologic diseases

Mechanism three: glutathione depletion and the oxidative stress spiral Peroxynitrite produced by mechanism one must be neutralized by glutathione (GSH)

Patients are advised to report any unexpected symptoms to their healthcare provider, and clinicians will typically monitor for symptoms of hypoglycemia or gastrointestinal upset during therapy