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An increased interferon gene signature was observed in patients with early RA (eRA), which predicted a poor response to the initial therapies in the first 6 months after diagnosis (8)

Demonstrates persistent cognitive benefits even after treatment cessation, suggesting true structural neurological improvements rather than temporary stimulation, supporting long-term brain health

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Another study found a strong association between plasma TNF- levels and KYN as well as KYN/TRP ratios, and patients with higher levels showed greater MDD severity and poor treatment response [104]