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Early pathological studies already showed ADEM to be characterized by perivascular demyelination associated with inflammatory infiltrates of peripheral immune cells, mainly macrophages, T and B cells ( Autoimmunity, even if not the only disease trigger, plays a large role in the production of autoantibodies and cytokine release

In this state, excess glucose is diverted into fatty acid synthesis via de novo lipogenesis, driven by the transcription factor sterol regulatory element binding protein-1c, which is upregulated under hyperglycemic conditions

Astruc, Organometallic Chemistry and Catalysis (Springer, Berlin, 2007), p

PMID: 71 ZhangDRenHXingYChenZ

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