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Theophylline was not shown to be teratogenic in CD-1 mice at oral doses up to 400 mg/kg, approximately 2.0 times the human dose on a mg/m2 basis or in CD-1 rats at oral doses up to 260 mg/kg, approximately 3.0 times the recommended human dose on a mg/m2 basis

Clinical patterns of facial melasma Reproduced with permission from Gupta M, Doolan BJ, Manungo F, Diagnosis of melasma and diagnostic tools, Opinions & Progress in Cosmetic Dermatology 2020;1:1518

Moreover, animal studies have reported that pre-treatment with metformin could reduce both myocardial and cerebral I/R injury (203, 204)

Many of the approved covalent drugs were discovered through serendipity

Avoid Harsh Products : Avoid using harsh or abrasive products that can further dry out your skin