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Curcumin targets the Keap1-Nrf2 pathway by modifying Keap1s thiol groups, destabilizing the Keap1-Nrf2 complex, and blocking Nrf2 ubiquitination

Shen et al., 2023), by disrupting blood-brain barrier integrity and inducing neuroinflammation (Lananna and Musiek, 2020

Wiersma, M

108 The protein kinase RNA-like ER kinase (PERK), eukaryotic translation initiation factor 2 (eIF2), glucose regulatory protein (GRP78), and growth arrest and DNA damage 153 (GADD153/CHOP) are all endoplasmic reticulum stress-related proteins