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In light of the fact that STAT3 not only blocks HIF-1 degradation but also increases synthesis of HIF-1 [90], it is likely that the STAT3-induced upregulation of PD-L1 expression is mediated by an increase in HIF-1 expression

Shao, X., Xu, H

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We also examined measures of cardiac structure and function through transthoracic echocardiography and invasive hemodynamics

How Mepolizumab Compares to Other Asthma Biologics Mepolizumab vs Other Severe Asthma Biologics: Side-by-Side Comparison Mepolizumab severe asthma treatment belongs to a revolutionary class of targeted biologics, but understanding how it compares to alternatives like dupilumab (Dupixent), benralizumab (Fasenra), and omalizumab (Xolair) helps patients and doctors select the optimal severe asthma biologics for individual needs