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Abnormalities in various metabolic pathways such as glucose 80 or amino acid metabolic system 81 in chondrocytes have been implicated in activating catabolic cascades in osteoarthritic cartilage 82

While the efficacy data did not survive the Phase IIb primary endpoint, the safety dataset across 900 participants is unusual for a research peptide and is consistently cited as the basis for continued investigational interest

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When an IM dose is about 80-90%, the body retains up to 50 mcg of the compound

Salicylic acid is amodulator of tobacco and mammalian catalases