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From a pharmacokinetic perspective, steviol glycosides are not hydrolyzed in the upper gastrointestinal tract but are metabolized by the intestinal microbiota into steviol, which is rapidly excreted in the urine without systemic accumulation

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Within the PDAC microenvironment interleukin-1 beta (IL-1) positive macrophages, prostaglandin E2, tumor necrosis factor, and lipocalin-2 can induce pro-inflammatory conditions ( Figure 3 ) (68, 88)