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During anaerobic fermentation, bacteria, anaerobic fungi, and protozoa continuously generate hydrogen as an electron sink to maintain redox balance

In the case of adhI , its promoter was shown to be activated by both formaldehyde and methanol, although induction by formaldehyde occurs more rapidly and at a lower concentration ( adhI is controlled by two separate, two-component regulatory systems: (i) AfdRS, which activates transcription in the presence of formaldehyde, and (ii) RfdRS, which is thought to act as a repressor, although the signal for derepression is unknown ( afdR and afdS are organized within an operon, as are rfdR and rfdS

77 Production, Management and the Environment: Small Ruminant

Belloni Fortina & Caroppo 2022)

GPX4 activity can be upregulated by supplementing intracellular selenium or glutathione, and also be inhibited by ferroptosis inducers such as ML162 and RSL3