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Since for most people it is impractical to take supplements several times a day, a single dosage of 250-500 micrograms seems to be the best solution

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This landmark study remains one of the strongest demonstrations of a neuropeptide's sleep-promoting activity in preclinical models Eur J Neurosci (2007) -- further characterization of cortistatin's sleep neurobiology, confirming the initial findings Anti-inflammatory studies -- cortistatin has demonstrated potent anti-inflammatory effects in multiple preclinical models (IBD: PNAS 2006, sepsis: J Leukoc Biol 2006, arthritis, atherosclerosis)

Excellent sources include: Meat and poultry : Beef, lamb, pork, and chicken (liver and kidney are particularly rich sources but should be avoided during pregnancy due to their vitamin A content) Fish and seafood : Salmon, trout, tuna, sardines, and shellfish such as mussels and crab Dairy products : Milk, cheese, and yoghurt Eggs : Particularly the yolk A varied diet including these foods typically provides well above the recommended 1.5 g daily