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(2018) suggest that SAA may confer protection against I/R-AKI, possibly due to its capacity to mitigate damage to PTC endothelium and to preserve PTC integrity, thereby alleviating hypoxia in the vicinity of renal tubules and ameliorating acute tubular necrosis

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doi: 10.1016/j.yexcr.2017.01.002 19 YazdaniHOKaltenmeierCMorderKMoonJTraczekMLoughranPet al

doi: 10.1073/pnas.95.2.510

Both in vitro and in vivo experiments suggest that Phgdh mRNA is mainly expressed in astrocytes and minimally expressed in neurons (Furuya et al., 2000)