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Concentration-wise, this ingredient is rarely used pure and usually shows up as part of a standardized centella extract where reported content ranges from 0.02-3.06%

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Physical Examination : General: The patient is a forty-nine year old caucasian female of Italian extraction in obvious acute and chronic distress from kidney and musculoskeletal disease

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The 20 to 35 years old participants received 200 mg Pycnogenol per day or placebo for 30 days, then switched to the other group for another 30 days