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The active (reduced) form is full of vigor and ready to do some heavy lifting

ME1 is a cytosolic NADP + -dependent ME involved in the generation of cytoplasmic NADPH for reductive biosynthesis and replenishment of the tricarboxylic acid (TCA) cycle intermediate by the reverse transformation of pyruvate to L-malate 5,6

Track symptoms meticulously since day-to-day variations are normal during this transition

doi: 10.1016/j.aca.2016.03.053

Faust et al , 2020), and the existence of a flexible hinge in the DDB1 adapter that allows for rotation of the catalytic subunit around the substrate receptor, thus creating a broad ubiquitylation zone to accommodate substrates of different size and shape (Fischer et al , 2011, 2014