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The maintenance of this mitochondrial GSH pool occurs through the action of a high-affinity GSH uptake system [43] which is a main determinant of neuronal susceptibility to OS [44]

Given the focus on retinal diseases such as DR, glaucoma, and AMD has been growing, understanding the role of DNA methylation in both retinal and brain diseases is becoming increasingly important

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For this reason, starting at the physiological dose of 0.3 mg and increasing if necessary is often recommended except for specific conditions where higher doses are therapeutically prescribed, such as jet lag, shift work, or cancer

doi: 10.1016/j.celrep.2012.08.043 73 GinderGDWilliamsDCJr