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These agents converge on key regulatory nodes: The AMPK/mTOR axis and the Sestrin-2/LKB1/AMPK cascade to provoke autophagy and cell death (95-97)

Because it works at the hypothalamic level, it stimulates the entire cascade naturally

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway

Intervening and treating oxidative stress is one of the most effective techniques for improving the pathogenetic status of ASD patients

SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation