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Despite differences in chronicity and etiology, both processes establish a self-reinforcing oxidative vicious cycle: excess iron promotes ROS generation via the Fenton/Haber-Weiss pathway, which in turn causes more cellular damage, further disrupts iron regulation (e.g., hepcidin suppression), and amplifies injury

Instead of doling out prescriptions for symptoms here and there, doctors who practice functional medicine look for and treat the underlying causes of disease, while providing the raw materials for optimal function

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10.1038/nature13961 81 LeeM.-R.KimJ.-E.ParkJ.-W.KangM.-J.ChoiH.-J.BaeS.-J.et al (2020)

identified similar syn accumulations in colonic biopsies from prodromal PD patients, further strengthening the hypothesis of a gutinitiated pathological process [20]