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While most people get enough B12 through their diet, some may develop a vitamin B12 deficiency due to dietary restrictions, underlying health conditions, or an inability to absorb the vitamin properly

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10.1002/biof.1449 100 PanchalS

This stable modification is achieved by either direct oxidation of protein-bound amino acids, oxidative cleavage of the protein backbone and incorporation of carbonyls from glycoxidation or lipoxidation

This is one reason results are inconsistent across studies, and one reason form and dose matter