glutathione peroxidase a selenoenzyme Rational redesign of the active site of selenosubtilisin with strongly enhanced activity Biological and Catalytic Properties of

7 , d793807 (2002)

Goldstein S, Samuni A, Merenyi G: Reactions of nitric oxide, peroxynitrite, and carbonate radicals with nitroxides and their corresponding oxoammonium cations

Journal of Alzheimers Disease, 42(4), 10791149

Although host metabolic adaptations that are shaped by evolutionary pressure in response to endemic viruses are conserved 7 , they may be dysfunctional in the context of emerging zoonotic infections

Notably, these findings collectively highlight that NPC ferroptosis is a confirmed promotor of IDD by impairing the viability of NP-residing cells as well as damaging the extracellular matrix (ECM) 7,8 , while the operation-induced physical and biochemical insults could significantly promote the ferroptosis cascades in NPCs to enhance the degenerative phenotype as well as aggravate the IDD symptoms