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At 24 h, the Intermediate and High DAP treatments for UCD522 led to similar gene expression profiles that were both different from the Low DAP treatment expression

10.1002/jcp.21101 22

Strikingly, lncRNAs are known to impact the AR protein interactome, the other key determinant of heterogeneity in ARs transcriptional action

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Conversely, mitochondria-derived ROS and pro-apoptotic proteins like Bax, Bid or Bim can trigger LMP, while caspase-8 regulates release of cathepsins [85]