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VLCKD Protocol: Step by Step As stated in the SIE position statement, the VLCKD protocol is divided into different stages, involving the drastic reduction of carbohydrate content for the first 812 weeks, to induce nutritional ketosis [21]

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Liposomes are small 'bubbles' that consist of phospholipids

The dysregulation of inflammatory/anti-inflammatory factors results in the infiltration of immune cells, concurrently activating signaling targets such as NF-B and MAPK, thereby influencing the expression of downstream proteins (intestinal barrier proteins, immune receptors, and related enzymes) (Dong et al., 2019), ultimately leading to an elevation in intestinal permeability (Wells et al., 2017)