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Alternatively, extracellular NAD + can be utilized by NAD + glycohydrolases, generating NAM, NR, or NMN outside of the cells, which can then be transported intracellularly for NAD + synthesis 65,66

30 In this case, the signal generated by the presence of radicals stimulates the production and transportation of specific antioxidants to the site of damage

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In humans, signs of withdrawal include anxiety, depression, and increased sensitivity to stressors 12,13,14 , which are positively correlated with alcohol relapse rates 15,16,17