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Polimeros 20, 287297

PLoS One 10 (6), e0131827

B-complex products run 50 to 500 mcg

On legality: it was never FDA approved, partly because its lethal dose is unknown

One observational study involving data from 135 migraine patients indicated treatment with folic acid was more effective than conventional treatment for reducing pain scores in carriers of the MTHFR mutation (Guo 2022)