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Measures of Disease Frequency of: HLA-B8 HLA-DR3 HLA-Drw52a Ischemic damage to the biliary ducts Bacterial infection leading to chronic or recurrent cholangitis Pathophysiology Environmental insult in susceptible individuals cholangiocyte activation cytokine production perpetual inflammatory response Chronic periductal inflammation Inflammation Inflammation is a complex set of responses to infection and injury involving leukocytes as the principal cellular mediators in the bodys defense against pathogenic organisms

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