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Among these, the AGE/RAGE signaling pathway was the most significantly enriched, supporting RAGE as a priority target

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While they play very different roles within the body, both contribute to maintaining healthy cellular function

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The cells were then harvested by centrifugation at 1000 g for 3 min at room temperature and resuspended in 100 mM MES/Tris buffer, pH 6, to an OD 600 of 7.5

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Physiological roles of radical ROS in cellular signaling and homeostasis A core principle governing the physiological roles of radical ROS, e.g., O 2 , is their spatially and temporally constrained nature

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