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In four randomized controlled trials (RCT) conducted in patients with obesity without T2D 15,16,17,18 , liraglutide 3.0 mg was compared to placebo as an adjunct to lifestyle optimization over 56 weeks, with the exception of the 3-year extension of the SCALE Obesity and Prediabetes study

[Abstract] Int J Mol Sci

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There was no significant difference of the mRNA levels of Cldn2 and Cldn4 among the 4 groups ( p = 0.1011.000 ), (Figure 3A)

These findings suggested that the LA1 mechanism of action differs in intestinal epithelial cells from that in immune cells