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An adequate and hopefully incisive therapeutic action will therefore depend on a finely orchestrated balance between the efficacy of the single treatment for the specific pathogenetic mechanism and the control of potentially noxious interactions among the different therapies

In the following sections, we summarize some of the most important aspects of mGSH physiology, its role in mitochondrial function and release of mitochondrial apoptotic factors and the impact of its depletion in disease

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