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this is not merely because the test is essentially useless but because many factors some of which are mentioned above

Multiple myeloma, a cancer of certain white blood cells HIV infection Pregnancy Use of oral contraception Use of the anticonvulsant drug phenytoin Blood disorders like chronic myelogenous leukemia or polycythemia vera Alcoholic liver disease, cirrhosis, or hepatitis Kidney disease Use of nitrous oxide, also known as laughing gas or whippets Autoimmune disorders Rare genetic disorders Interpretation of test results depends on various factors, including symptoms, medical history, and other laboratory findings

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Leitner et al., 2014 hypothesize they share a common genetic cause