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Results tRF levels in CSF show PD-specific changes To seek PD-characteristic tRF profiles, we analyzed a short RNA sequencing (RNA-seq) dataset (phs.000727) 38 consisting of postmortem (PM) CSF samples from 46 patients with PD, from 53 patients with Alzheimers disease (AD) and from 53 healthy controls (15, 27 and 24 females, respectively

This creates a harmful cycle - more ROS damages DNA further, which activates PARP1 and uses up more NAD+

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Mostofa MG, Rahman A, Ansary MM, Watanabe A, Fujita M, Tran LS