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Targeting of proteasome 20S peptidase activity with bortezomib and carfilzomib has been widely used to treat myeloma

Figure 4 5 Role of intestinal flora and its metabolites in cardiovascular and cerebrovascular diseases and regulatory strategies for engineered bacteria With the introduction of new concepts such as the heart-gut axis and the brain-gut axis, changes in the gut microbiota and cardiovascular diseases, two seemingly unrelated conditions, have been tightly linked

The role of iron in AMD has also been evidenced in various animal models of iron overload that mimic features of AMD [51, 52]

Moreover, the increase in international air travel between countries with endemic dengue, often popular tourist destinations, and regions without the disease has heightened the risk of transmission [96]