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-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia

[DOI] [PMC free article] [PubMed] [Google Scholar] (206).Urban-Klein B

Bioremediat J 137

Sangha V, Aboulhassane S, Bendayan R (2024) Regulation of folate transport at the mouse arachnoid barrier

Sermorelin has been specifically studied in elderly populations for GH restoration, and the overlap between these two age-related declines creates a rationale for sermorelin to address both simultaneously