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Considering that NO is an important signal transduction molecule [4, 5, 17,18,19,20,21], the nitrosative stress tolerance of the two parental strains ( akuB KU80 and Af293) was different (Additional file 3), and the absence of MeaB reduced nitrosative stress tolerance (in strain Af293

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ApoE2 and ApoE3 bind preferentially to small phospholipid-rich HDL, while ApoE4 is found to bind preferentially to large triglyceride-rich VLDL (Nguyen et al., 2010)