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ROS can induce AP-1, a heterodimer composed of c-fos and c-jun, which downregulates type I collagen and upregulates MMPs in aging skin [77], and can also inhibit the TGF- signaling pathway in skin fibroblasts

This finding was similar to that of a previous study by The serum iron could reflect hepatic iron accumulation, which is considered an important factor in the progression of liver fibrosis ( On exposure to a toxic dose of APAP, ferrous iron is released into the cytosol from the ruptured lysosomes ( The current results showed that APAP treatment induced a statistically significant increase in MDA and a decrease in GSH levels compared to the control group, while PA produced a significant improvement in oxidative stress by decreasing the MDA level and increasing the GSH level compared to the APAP group

Parker H, Winterbourn CC (2012) Reactive oxidants and myeloperoxidase and their involvement in neutrophil extracellular traps

Diverse functions of myosin VI elucidated by an isoform-specific -helix domain

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