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To realize this potential, the field must prioritize well-structured clinical trials with biomarker-based outcomes and long-term safety evaluation

Although the mechanism has not been fully explored, recent studies suggest Toll-like receptors (TLRs)-related pathways might play an essential role in this process (27)

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Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport

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