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Furthermore, epigenetic memories have been shown to persist in human adipose tissue, denoting incomplete recovery of metabolic function, and may explain the accelerated rebound obesity in individuals with subsequent exposure to obesogenic lifestyles, after substantial weight loss [163]

(2017) 49:e358

Saito K, Siomi MC

A similar result was reported for flubrotizolam (Gameli et al

Functional MET channels are required for aminoglycoside ototoxicity, and increased channel open probability during acoustic stimulation enhances drug entry ( Once inside, aminoglycosides accumulate within hair cells to concentrations that persist for months owing to high-affinity binding to phosphatidylinositol 4,5-bisphosphate ( Mitochondrial dysfunction Aminoglycosides preferentially localize to mitochondria by binding to the 12S ribosomal RNA, which is encoded by the mitochondrially encoded gene MT-RNR1