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doi: 10.1615/CritRevImmunol.v31.i5 [DOI] [PubMed] [Google Scholar] 218

The escalation schedule exists for a reason

HanMGieseGSchmitz-ValckenbergSBindewald-WittichAHolzFGYuJet al

Therefore, the p53-p21 and p16-pRB tumor suppressor pathways are canonical to cellular senescence

When liver damage progresses to acute liver failure, N-acetylcysteine (NAC) serves as the primary treatment to replenish glutathione and prevent further hepatic injury