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doi: 10.1016/j.cgh.2013.06.019 4 PicornellYMeiLTaylorKYangHTarganSRRotterJI

This combined effect may be due to the induction of apoptosis, but may be not through the induction of ROS production or MAPK pathway activation [103]

In vivo models commonly used in this research include collagen-induced arthritis (CIA) in rodents, monosodium iodoacetate (MIA) cartilage injury models, and surgical destabilization of the medial meniscus (DMM) models for osteoarthritis

However, these effects were reversed following the addition of the SIRT1 inhibitor NAM

Dose-by-question framing In research planning, the question dictates the dose