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7.4.2 Emerging therapeutic dilemmas in DM-pulmonary comorbidity management While the causal relationship between DM and pulmonary disorders remains incompletely elucidated, the clinical management of their comorbid status presents emerging challenges

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Depletion of PAPS due to lack of inorganic sulfate or due to genetic defects of enzymes participating in PAPS synthesis may lead to reducing of sulfonation capacity which could affect the metabolism of xenobiotics or disrupt the equilibrium between synthesis and degradation of active endogenous compounds

Oral administration of octacosanol modulates the gut bacteria and protects the intestinal barrier in ulcerative colitis mice

It is also possible that not only EWS itself but also its associated products contributes to the transcriptional regulation of TERRA