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Collagen and elastin synthesis strengthens the extracellular matrix that supports both skin and hair follicles

Meanwhile, autophagy could be activated by rapamycin via PI3K/mTOR signaling pathway, and thus, protects hippocampal neurons from degeneration by decreasing the levels of prooxidants (Kotagale et al., 2020)

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It also increases antioxidant enzyme activity (SOD, catalase, and glutathione) to combat oxidative damage from any source

Genetically susceptible follicles, particularly those at the crown and temples, possess higher concentrations of androgen receptors, making them more vulnerable to DHT-induced damage