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Accordingly, pharmacological inhibition of SLC7A11 or cysteine deprivation blocks GSH synthesis, leads to GSH depletion, and induces ferroptosis by disabling the antioxidant defense system 85,137

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This peptide was used alone, without carrier, and that this is an important advantage over the conventional peptides that have to use carrier (thereby peptide+carrier-complex) and mostly local use only, particularly in bone healing (28)