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In humans, upon detecting oxidative stress, the NRF2 partner KEAP1 no longer ubiquitin-labels NRF2 for degradation, resulting in NRF2 stabilization and activation of NRF2-response genes

Hirota K, Murata M, Sachi Y, Nakamura H, Takeuchi J, Mori K, et al

Nonetheless, cycling usage (e.g., eight weeks on, four weeks off) and medical supervision are recommended, especially for those with pre-existing kidney or liver conditions

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EAAT2 expression contributes to around 95% of total glutamate transport activity and represents approximately 1% of the total brain protein in the CNS [10], therefore, playing a key role in the maintenance of extracellular glutamate homeostasis