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When the oxidative stress state persists and the damage progresses, senescent cells enter a senescent state marked by p16 upregulation, which consequently inhibits the kinases CDK4 and CDK6, thereby maintaining the stagnant state of the cell cycle [133, 134]

High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ nave lymphocytes and prevents TTV reactivation