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N.NachiappanV

RNA-seq and differential gene expression analysis was performed by GeneWiz

ROS-low LSCs showed significant 13 C 16 palmitate uptake which was incorporated into the TCA cycle intermediates citrate and malate (18)

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Concomitantly, as pharmacological NPC1 inhibition leads to a reduction in esterified cholesterol due to the lack of cholesterol transport to the ER, this likely contributes to the moderate increase in total cellular cholesterol levels determined biochemically when compared to controls (Supplementary Fig