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doi: 10.1152/physiolgenomics.00194.2006

From a CPMG-based LO-NMR fragment screen, we identified one naphthalene sulfonic acid fragment hit ( 27 ) that binds to TRF1 TRFH with triple-digit micromolar affinity as measured by the R2KD assay

Experimental evidence suggests an involvement in vascular remodeling through stimulation of new microvessel development, alongside regulation of nitric oxidedependent signaling