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Visceral adipose depots (e.g., mesenteric and omental fat), being the first fat reservoirs encountered in portal circulation, preferentially sequester and utilize these abundant lipogenic precursors, leading to their rapid expansion [76]

The therapeutic clinical approach continues to seek solutions through pharmacological meanssuch as inhibitors and antibodieswhich, while sometimes controlling symptoms, have not addressed the underlying pathophysiology

Data availability Original data generated and analyzed during this study are included in this published article, the supplementary material, or are available from the corresponding authors on reasonable request

& Bader, R

The intrinsic factor made by the parietal cells of the stomach attaches to the B12 to be shuttled to the ileum where receptors pull it into the blood