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While healthy NAD+ levels support mitochondrial health, it is MOTS-c that is more directly linked to promoting mitochondrial biogenesis (the creation of new mitochondria)

While toxicity is rare, excessive intake of certain B vitamins (particularly B or B) from multiple sources could increase the risk of side effects (like niacin flush or peripheral neuropathy)

Notably, she also exhibited neurological manifestations, which is rare at her age