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Ashwagandha sometimes is better tolerated (it works more on GABA and cortisol), but some slow COMT individuals even find ashwagandha stimulating or too much. Ginseng (especially Panax ginseng) can raise dopamine and adrenalinelikely not ideal for slow COMT

Uncropped scans of fluorescent gels and gels stained with Coomassie blue are provided in Supplementary Figs

PMID: 52 TangCPClarkOFerraroneJRCamposCLalaniASChoderaJDet al

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Some studies suggest that lactate is a more efficient energy substrate than glucose, with evidence indicating that neurons generate energy more effectively when utilizing lactate (Dienel 2019)