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This was observed in a cohort of patients that met the Rome criteria for the entity, of whom only 4% were diagnosed with CVS.4 These data highlight the poor recognition of the syndrome, resulting in diagnostic delay and the consequently greater frequency of visits to the emergency room, increased health costs, and suboptimum treatment, with poor results for the patient.3,5,6 Thus, our aim was to carry out a detailed bibliographic review of the epidemiology, pathophysiology, subtypes, diagnostic criteria, and current management of CVS

10.1016/j.devcel.2018.09.020 5 CaniP

doi:10.3109/00365513.2011.646299, PMID: 22208644 Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA (2007) N -acetylcysteinea safe antidote for cysteine/glutathione deficiency

if you do not experience any improvement within the expected timeframe after taking ondansetron, this may suggest the need for dose adjustment or alternative therapies